Biological evolution is change in the characteristics of living organisms over generations.
Despite your vastly superior tastes in music and fashion, you probably look vaguely like your parents, just as they look vaguely like their parents. For all of recorded history, people have looked more or less the same: two eyes, two ears, a nose, a mouth, a head sitting atop an oblong body with two arms and legs. Hairdos differed, but the basic body plan stayed the same for as far back as the history books go.
But if you were to go back further in time, a couple million years before anybody figured out how to write, your ancestors would still have two eyes, two ears, a nose, a mouth, a head sitting atop an oblong body with two arms and legs. But they would have more hair. And maybe not quite as much smarts. They would be much better at climbing trees, though. If you went further back in time, the arms would be front legs. Even further back in time, the fur would be scales. Really far back in time, there wouldn't be any legs at all, just fins for swimming.
Evolutionary theory argues that all the organisms alive on earth today share a common ancestor. As unlikely as it sounds, life forms from spiders to spider monkeys belong to the same family tree. Even fungus merits an invitation to the family reunion. A simple way to think of evolution is "descent with modification" — over many generations, organisms change into something different.
People took a long time to figure out that evolution happened, and for many years, Western civilization relied largely on the Bible to understand how we got here. But about the same time that Anglo-Irish Archbishop James Ussher calculated his earth-formation date of October 26, 4004 BC, some of his keenest contemporaries puzzled over just how the Bible could be literally true. Early on, the story that caused perhaps the most trouble was Noah's Flood.
One man who managed to stir some doubt was Niels Stensen (or Nicolaus Steno). A religious man, Steno wasn't out to disprove the Bible; he used it as the basis for his work in piecing together old landscapes. He figured out that rocks are deposited in layers with older rocks at the bottom, and in the landscape of Tuscany, he thought he saw the events described in Genesis. In the century following his death, however, people who searched rock layers for remains of earth's earliest inhabitants found something odd. According to Genesis, God made Adam, Eve, and all the animals first. Then Adam and Eve started a family and left plenty of descendents. Only later came Noah's Flood, which was held responsible for depositing all those weird remains, like shells, in rocks on top of mountains. If that actually happened, human remains should have appeared in the oldest rocks at the bottom of the heap, but they didn't. Human remains showed up only in the newest layers. The oldest layers of rocks held different creatures, and the further down in the heap one looked, the weirder the creatures got.
Steno wasn't alone in inadvertently causing Noah trouble. All the naturalists who traveled to the New World and Australia to draw, collect, measure and catalog what lived there threatened to sink Noah's Ark with too many passengers. After all, fitting two of everything living in Europe was enough of a challenge. Squeezing in all these newly discovered creatures from newly discovered continents looked impossible. Biblical scholars went back to calculating the length of a cubit.
One more problem for Noah was a shift in philosophy in the 17th and 18th centuries. Rather than simply relying on miracles, scholars and savants (there were few actual scientists just yet) adopted the view that God played by His own rules, so understanding nature could contribute to understanding God. And if God played by the rules, then a worldwide flood that covered the highest mountain peaks with water (and left seashells behind) would require the sudden creation and subsequent cleanup of a tremendous amount of liquid. That didn't look likely. Leonardo da Vinci himself poured scorn on such "just so" stories.
By the early 19th century, a different picture had emerged of the planet's history. Lead by scientists like Buffon, George Cuvier and James Hutton, the men (few women could participate then) who studied rocks and fossils accepted that the earth had been around for thousands, if not millions, of years before people came on the scene. Furthermore, many animals — giant ground sloths in South America, monstrous reptiles in England — had gone extinct long ago. So even if people continued to look to the Bible for spiritual guidance, they began to doubt it was a literal account of the history of life on earth.
Not everyone who accepted an ancient earth necessarily accepted biological evolution. By the early 19th century, the professional scientists and leisurely gentlemen who dabbled in geology or comparative anatomy entertained a variety of explanations for humanity's predecessors. Evolution was one explanation, but many savants believed a series of catastrophes had been followed by fresh creations.
One early evolutionist, Lamarck, proposed a form of evolution in 1800. He suggested that organisms could acquire needed characteristics for changing environments, an idea that has been laughed off by history, but his views were actually more nuanced than modern accounts usually relate. Cuvier, regarded as the greatest comparative anatomist of his day, disdained Lamarckian "transmutation" but that didn't keep others from considering it, such as Erasmus Darwin, Charles Darwin's grandfather.
At the end of 1831, Charles Darwin set sail on a sea voyage. Over the next several years, he examined living and fossil organisms that gave him an insight into the ancient past. When he departed on his voyage, many of the people he knew believed in special creation, meaning that God specially created every organism for its environment. At the time, Darwin himself may have shared that belief. Early on, however, he noticed phenomena that special creation didn't explain very well. When introduced to islands, frogs often thrive, sometimes multiplying to nuisance proportions. Yet on the Galápagos, Darwin couldn't find any frogs. He instead affirmed what the French naturalist Jean Baptiste Geneviève Marcellin had said earlier: frogs aren't found on very many oceanic islands, even when they are well suited to those environments. It begs the question why they weren't created for those locations. The situation is more easily explained by the theory that life on earth evolved, had to migrate to new locations, and would be prevented from doing so by substantial barriers. Where barriers to migration exist, different animals fill the same ecological niches. This happens again and again, with rabbits and viscachas, beavers and capybaras, and jaguars and marsupial lions filling similar niches in different locations.
Some time after he returned home, Darwin developed his theory of natural selection. He planned to publish his idea as early as the 1840s, but then Robert Chambers anonymously published Vestiges of the Natural History of Creation a quasi-scientific account of organisms changing over time. The reaction was fierce. Darwin held back — and gathered more evidence to support his case. In the late 1850s, a young naturalist, Alfred Russel Wallace, began to see organisms in the same light as Darwin. He wrote Darwin about his idea, and Darwin realized that, if he waited any longer, he would be scooped. Darwin's notes and correspondence, and Wallace's paper were all read aloud at the same scientific meeting in 1858. They spurred little reaction, but a year later, Darwin published The Origin of Species. Biology was forever changed.
Darwin has gotten more modern attention than Wallace, but they both deserve credit for the theory. They're famous today not because they proposed evolution. That had already been done. They're famous for proposing a viable explanation of how evolution occurs: natural selection.
In the wild, most parents produce more babies than can possibly survive. When sea turtles hatch, hundreds of them poke out of their shells and head for the ocean, desperately flopping their tiny legs as fast as they can. Many of them don't even reach the water; they're picked off by seagulls instead. Once in the water, many more baby turtles become snacks for their neighbors in their new watery neighborhood. Even if they avoid becoming a meal themselves, they have to find meals of their own, and food can be pretty limited in the wild.
Some life forms on earth — such as some bacteria, plants, even animals — reproduce by cloning — making exact replicas of themselves. In such populations, everybody is the same. For the rest of us, sex introduces variation into a population. Darwin pondered this variation, particularly the differences between the animals that survive and pass their characteristics on to their offspring, and those that instead get snatched up in the jaws of defeat. He (and Wallace) found that the key to surviving and producing offspring has to do with suitability to the environment. Birds that need to see their prey from afar, then swoop down and snatch up a meal, benefit from keen eyesight. Hunting birds with lousy eyesight often go hungry. Lizards scurrying around in forest floor litter benefit from good camouflage and swift legs. In a (literal) pinch, the ability to part with one's tail can keep a lizard alive. Ditto an octopus arm.
In other words, the life forms best suited to their environments are likely to live the longest and produce the most offspring.
An assortment of tiny islands in the Bahamas recently gave researchers the chance to compare the roles of predation and competition in natural selection. The scientists stocked each island with lizards that they planned to observe, careful to ensure no reptilian island-hopping. Even before that, they measured and marked each lizard, and put each (un)willing experiment participant through a fitness test on a treadmill. Some islands were sparsely populated, meaning the lizards' biggest challenge was predation. Other islands were crowded, so the biggest challenge in those places was beating the other lizards to the most calories. At the end of breeding season, the researchers sifted through their results and discovered that competition for resources was a bigger driver of natural selection than predation. Local predators turned out to be unfussy eaters. The lizards that won the chow contest on crowded islands, however, were bigger and more athletic than the survivors on un-crowded islands.
Even when an organism is well-suited to a particular environment, and can out-compete others for limited resources, that's no guarantee of everlasting success. Environments can change. Lakes can dry up. Weather patterns can shift. A new species of vegetation can set up camp, favoring a new color of camouflage in lizards rustling around in the leaves. Any organism that happens to possess a characteristic well suited to the new environment will do better than its peers. Over time, the new characteristic may become so preferable to the old one that the population eventually looks different from how it used to look.
Darwin couldn't know about the discoveries of genetics that would follow in the 20th century. Genes — the inherited instructions that tell our cells what to do and tell our bodies what to look like — are passed from one generation to the next with remarkable accuracy. But every once in awhile, something goes wrong. The instructions get botched. These random mistakes are mutations. People often think of mutations as invariably harmful, but that's not always the case. Many (perhaps most) mutations have little or no effect, and some mutations are life savers. One example in human DNA is known as delta 32. When the plague, often referred to as the Black Death, struck Europe, it devastated the population, but a lucky few survived. They carried the delta 32 mutation that conferred resistance to the disease. The same mutation appears to confer a resistance to HIV, the virus that causes AIDS, today.
If your irritating little brother emptied a pail of sand over your school project, while you stood there thinking of ways to shorten his life, the little tyke might try to extricate himself with the argument that he had no idea the sand would actually fall down. After all, gravity's just a theory.
In casual conversation, we talk about our "theories" all the time, i.e., "Men who are chauvinists at work are really henpecked at home, and they're just trying to vicariously get even with their wives." A scientific theory is different. Rather than being simple speculation, a scientific theory tries to make sense of a broad range of observations. The germ theory of disease is a good example. Before scientists understood the role that microscopic pathogens play in spreading sickness and infection, people used to blame cold weather, warm weather, "vapors," foreigners, even evil spirits. Today, the germ theory of disease is so well accepted that a doctor who refused to wash up before performing surgery would face a lawsuit, and probably lose his or her license to practice medicine.
A scientific theory starts out as a hypothesis, a proposed explanation for some phenomenon, and where possible, the hypothesis is subjected to testing. Scientists document such work and publish their papers in peer-reviewed science journals. Other scientists in the same discipline review and comment on the paper before it sees the light of day, and other researchers should be able to replicate the experimental results.
As evolutionary biologists have pointed out, any of the experiments designed to test Darwin and Wallace's theory of natural selection since it was first proposed could have proven the hypothesis wrong. None of those tests did. So evolution is "just a theory" the same way that the theory of plate tectonics and the germ theory of disease are just theories. And gravity.
One body of evidence Darwin turned to for his theory was artificial selection: the changes humans have caused in crops, livestock and pets.
Humans have bred dogs, birds, cows and flowers to their desires for hundreds, if not thousands, of years. Dogs may be the first organism that people domesticated, and in the thousands of years that have passed since humans began breeding our canine companions, we have shaped dogs into a mind-boggling variety of colors, shapes and sizes. Depending on the breed, an adult dog might fit easily into your purse or backpack, or weigh more than you do. It might be specialized for speedy running, fetching, rat killing, thief watching or lap sitting. (Though they also show significant variety, domestic cats exhibit a smaller range of sizes and shapes than dogs, and no amount of human intervention in their breeding process has rendered cats and sweet and devoted as dogs.)
Human intervention in crops is easily to underestimate, but domestication has shaped the foods we eat as much as dogs and cats. A 17th-century still life by Giovanni Stanchi hints at how much humans have changed plants in just a matter of a few centuries. The exotic-looking fruits in the lower right of Stanchi's painting are watermelons — hard to recognize for modern viewers.
If farmers and breeders could bring about such big changes in the short time span of recorded history, Darwin reasoned, what could nature do?
Artificial selection shows the power of an outside selective force acting on a species, but that's not the only evidence for evolution. Other factors point to common origin for life forms. Bats, dolphins and people are all mammals, but bats fly, dolphins swim, and humans type, dine and doodle. If each species were carefully designed from scratch, there wouldn't be much need for overlap in skeletal structure. Yet all three types of animals share the same general limb design. Humans, dolphins and bats all have upper arm bones, lower arm bones, wrists, hand bones, and fingers. In dolphins, these bones are shortened to make a stiff flipper. Bats, meanwhile, spread their wings out over their finger bones.
Why would evolution do this? Because it works with whatever it's got handy (pardon the pun). Evolution can't see the future and it can't change the past. It can only cope with the present.
Another example of evolution working with what it's got appears in the difference between how whales and fish swim. Fish and their ancestors have always lived in the water. Whales moved back into the water after their ancestors wandered around on land. When fish swim, they wriggle their tails sideways, rather like a snake slithers. In contrast, whales move their tails up and down, because they inherited spines that were once attached to running legs.
One of the arguments mustered against Darwin's theory was the complexity of the human eye, which couldn't function properly without all its components working just right. Surely something so complex couldn't evolve through gradual change, critics argued. But more primitive eyes can be found in nature. Freshwater flatworms get by with simple eyespots: aggregates of pigment cells that distinguish between light and darkness without the aid of nerves.
Darwin pointed out the things he and his contemporaries could observe in the 19th century. In the 20th century, the neo darwinian synthesis combined Darwin's theory of natural selection with Gregor Mendel's discoveries related to genetics, and not long afterwards James Watson and Francis Crick uncovered the physical structure of DNA. This led to a whole new set of discoveries about common ancestry.
People began domesticating rock pigeons, Columba livia, as long ago as the Neolithic, and by Darwin's day, pigeon breeds abounded. Darwin suspected that all the pigeon breeds, even the "fancy" pigeons with strange shapes and frilly feathers, descended from the rock pigeon. Genome sequencing of pigeon breeds in the early 21st century backed up Darwin's suspicions, showing that domestically bred pigeons are more genetically similar to each other than to another closely related pigeon species, Columba rupestris. The research also identified a mutation matching crests (feathers growing in reverse direction) on multiple species, likely a mutation that "occurred just once and spread to multiple breeds." The domestic pigeons had derived traits their ancestor breed lacked.
DNA studies have found that some organisms carry long-deactivated genes that were more useful to their ancestors. Dolphins and whales, for instance, carry hundreds of genes related to sensing smell in an air-based (not water-based) environment. But because these animals have returned to the water, those genes are no longer functional.
DNA studies help humans find our own spot in the tree of life. Comparing the genetic material of humans and other great apes shows that our DNA differs within our own species by about 0.1 percent, with that of the chimpanzees by about 1.2 percent, and with that of the gorillas by about 1.6 percent. Yet humans and African apes (including gorillas) all share more similar DNA than the African apes share with orangutans, which dwell in Asia. Darwin predicted that humans branched off from other apes in Africa and modern studies back up his hypothesis.
More striking than similarities among great apes are DNA similarities between a much wider range of animals. Analysis of human versus fruit fly DNA indicates that we use basically the same genes, just in different ways with different combinations and different timing. Scientists have also pinpointed some specific genes that do different things in different organisms. Research led by Arhat Abzhanov of Harvard University suggests that a gene that geneticists have dubbed BMP4 both strengthens the jaws of fish that eat a robust shellfish diet, and bulks up beaks of Galápagos ground finches. A 2015 study by Sangeet Lamichhaney and coauthors found that a different gene, ALX1, plays a strong role in beak formation in Darwin's finches, as well as facial structure in humans. Another gene identified as FOXP2 helps young finches learn to sing, and young humans to speak.
Over the course of their evolutionary history, many organisms have lost genes, but sometimes the function of the discarded gene can be regained by repurposing genetic material the species has left. Many vertebrate species possess three genes related to taste, named T1R1, T2R2 and T3R3. Among this trio, T2R2 gives humans and other animals the ability to taste sweet foods. Genetic studies indicate that birds have lost the gene that would enable them to appreciate a candy store. But nectar-sipping hummingbirds show a clear preference for a sugary diet. A study led by Maude Baldwin in 2014 concluded that hummingbirds had repurposed T1R1 and T3R3, which pair up to sense umami (savory) flavors, to sense sweet ones as well. Baldwin postulated that hummingbird ancestors might have been introduced to a sweet diet by hanging out near flowers to catch insects. If so, it would bolster Darwin's claim that taste "must be acquired by certain foods being habitual — [and] hence become hereditary," though Baldwin cautioned that more evidence, such as early hummingbird fossils, was needed to flesh out her hypothesis.
Gene studies have turned up groups of genes, sometimes called modules or termed "deep homology," that have continued working with each other for (literally) millions of years. Like steadfast bowling buddies, these genes have stuck together even as the organisms they created evolved and the genes' jobs changed. A hunt for genes that code human blood vessels, for example, identified five genes — and turned up the same genes in an astonishing place: yeast. In these unicellular fungi, the genes repair damaged cell walls. A hunt for genes involved in the human nervous system found the same genes in completely nerveless protists known as choanoflagellates. Human eyes and jellyfish eyes use the same clusters of genes to detect light. So far, geneticists have detected almost 50 modules shared by people and plants.
And then there are genes that manage the big picture in a variety of organisms. First found in fruit flies, hox genes regulate overall body plans for everything from bugs to birds. Arguably grisly experiments with these genes show that moving them around creates fairly disgusting mutants, like flies with legs sprouting from their heads.
Even more basic than hox genes are the building blocks for all genes; DNA is the acronym for deoxyribonucleic acid. With the exception of some viruses that rely on just ribonucleic acid (RNA), all life on earth uses DNA. And in organisms with DNA, RNA helps transcribe genes into proteins. These building blocks of inheritance are common all living things on this planet.
Evolution still happens today, and it's still driven by natural selection.
Finches in the Galápagos Islands — the same archipelago credited with kick-starting Darwin's thoughts about evolution — lured succeeding generations of scientists to its shores to study the plants and animals that live there. Biologists Peter and Rosemary Grant began their own studies of Geospiza fortis finches in the 1970s, and found that drought conditions favored bigger beaks, and wet seasons favored smaller beaks. In both cases, the Grants and their assistants found measurable changes in beak size.
As the glaciers retreated at the end of the Pleistocene 10,000 years ago, migratory marine fish moved into lakes and streams in North America and Eurasia. Adapting to new foods, new threats and new water conditions has diversified these stickleback fish (Gasterosteus aculeatus) so much that they show greater diversity in their body plans than different genera of fish. Variations include dramatic differences in the size or number of bony plates, body build and tooth structure. Some sticklebacks sport fins that other sticklebacks completely lack. And because sticklebacks often stick to their own size when it comes to mating, that promotes isolation of different reproductive groups. In the shorter term, scientists put developmental pressure on stickleback fish in an experiment published in 2008. The researchers fed two different diets to fish in captivity. Some of the fish fed on bloodworms wriggling around the tank bottoms while others feasted on shrimp in the water column. The bloodworm eaters developed stumpy snouts with wide mouths, and the shrimp eaters developed long, skinny snouts.
The 2008 stickleback study did not result in the evolution of a new species but it documented something intriguing about how evolution can work. One of the gadgets in many organisms' evolutionary toolkit is plasticity: the capacity to develop in different ways when faced with different conditions. Fish known bichirs (Polypterus) inhabit lakes and rivers, but can "walk" short distances over land using their fins and breathing air with primitive lungs. An experiment published in 2014 put the fish on land over the course of their lives. The fish developed a more efficient gait, placing their fins under their bodies. Their shoulder joints loosened, allowing for greater movement. The changes in bichirs resembled the changes seen in fossil record of tetrapods.
Off Florida's Gulf Coast lies a geologically young island archipelago, inhabited by pale-hued mice, Peromyscus polionotus. The mice have light coats, making them mix better with pale beach sand than their darker mainland mice relatives, and the lighter coats result from small changes in the expression of a single gene during embryonic development. The beach mice's genetic mutation occurred after the beach islands formed some 6,000 years ago.
Bird lovers who stock bird feeders for European songbirds known as blackcaps, or Sylvia atricapilla, have managed to encourage two groups of birds, one that eats fruit and winters in the Mediterranean, and another that dines at bird feeders while wintering in the UK. The UK birds have rounder wings and skinnier beaks.
Between 1947 and 1977, General Electric released polychlorinated biphenyls (PCBs) into the Hudson River. PCBs can cause nasty deformities in fish larvae, such as missing jaws. But recent observations of one type of bottom-dwelling fish, tomcod, showed that they didn't suffer from PCB-induced deformities. It turns out that most tomcod in the New York region carry a beneficial mutation in a gene named AHR2. Normally PCBs latch onto the proteins encoded by AHR2, but the useful mutation enables the proteins to evade the PCBs' grasp. Farther away from the source of PCB pollution, fewer tomcod carry the mutated gene; hardly any tomcod in northern New England or Canada have it.
Studies of mosquitoes in the London Underground (subway system) have turned up new speciation — in Darwin's own neighborhood, and since the publication of Origin. Culex pipiens is the world's most widespread mosquito species. In London, it occurs in two varieties: C. pipiens pipiens, which lives above ground, and C. pipiens molestus, which lives underground. At high latitudes, the mosquito species are quite distinct from each other, partly because only the surface variety goes into hiding and stores fat during the winter. In the 1990s, a pair of geneticists began studying mosquitoes in London's Underground. Like subterranean mosquitoes elsewhere, the Underground bugs stayed active in the winter months. Yet the geneticists found that the Underground mosquitoes showed the greatest genetic similarity to local mosquitoes that lived at the surface. Furthermore, the mosquitoes inhabiting the subway system showed far less genetic variation than their relatives up top — evidence of a much younger population. When the researchers tried mating Underground bugs from different parts of the subway system, they had no trouble making babies, but when the researchers tried breeding them with surface varieties, no babies resulted. The evidence indicates that a group of surface mosquitoes took up residence in the Underground (which first came into use in 1863) and, in reproductive isolation, established a new species.
Mosquitoes aren't the only bugs to provide clues to speciation. Chalkhill blue butterflies (Polyommatus coridon) settle in chalk- or limestone-rich environments, feeding on horseshoe vetch and laying well-camouflaged eggs on the plant leaves. Chalkhill blue larvae secrete a sugary solution prized by multiple species of ants. Guarding their source of ant candy, the tiny attendants protect the butterfly larvae from wasps and other troublemakers. Entomologists have identified multiple varieties of Polyommatus coridon, and studies of the butterfly's genes in the mid-1990s indicated that a variety in Sardinia was evolving away from continental populations, likely driven by isolation. The butterfly population in the Sardinian mountains was small, and had far less genetic variation than the continental varieties.
Creationists have often argued that evolution has never been observed, and even many biologists assumed that evolution happened too slowly to be observed within a human lifespan, but that assumption turns out to be wrong.
Two bug species probably made their way to the Hawaiian Islands around the turn of the last century: Ormia ochracea (a parasitic fly from North America) and Teleogryllus oceanicus (a cricket from Oceania). Like boys everywhere, the male crickets tried to win girlfriends with noise, in their case by rubbing their wings together. But in the presence of the flies, who find the sound as attractive as female crickets do, and whose larvae like to burrow into the males and kill them from the inside, silence turned absolutely golden. Within as few as 20 generations, male crickets on two islands got much quieter, actually losing their chirping abilities. About 50 percent of the males on Oahu, and about 95 percent of the males on Kauai lost the wing structures that make the love songs humans hear as chirps. Not only did entomologists observe these changes over a short time, thanks to the bugs' short lifespans, but they could also see the differences in the wings between the island populations. A study published in 2014 reported that DNA analysis showed different markers in the genomes of the Oahu and Kauai crickets — an example of convergent evolution, where different populations independently evolve similar traits.
Working in the Guanapo River Valley in Trinidad and Tobago, biologists developed an ingenious method for marking guppies with microscopic beads under their skin, making each guppy unique, then tracking what happened to them. Since the 1970s, the studies have led to a series of discoveries. One is that guppies living in largely predator-free stretches of the river turn out to be more flamboyantly colored than their drab cousins who hope to escape the dinner plate downstream. After transplanting drab guppies to the safer stretches upstream, the researchers found that the dull little fish evolved pretty color patterns within just five fish generations. Another finding was that fish transplanted into tough neighborhoods evolved to mature sooner at smaller sizes, putting more resources into making their own fast-growing, compact babies.
In the 1950s, engineers were building the Intracoastal Waterway, and their dredging off the coast of Florida produced byproduct islands. Carolina anole (Anolis carolinensis) lizards soon took up residence. In 1995, scientists conducted an experiment by introducing a new species, the brown anole (Anolis sagrei) — a closely related species and a competitor — to some of the islands. The scientists had two predictions: (1) The Carolina anoles would move to higher perches to avoid the unwelcome guests, and (2) This change in behavior would have "an evolutionary consequence." The first prediction came true within just a few months. The second came true in just 15 years. The Carolina anoles quickly took up residence in higher branches, and their toepads enlarged to enable a better grip. The change took about 20 lizard generations.
Bacteria generally reproduce so quickly that humans can observe multiple generations in the space of a day, and this has enabled scientists to observe evolution. Experiments published in 2013 tested multiple generations of a bacteria species that occurs everywhere from soil to human skin to human lungs, Pseudomonas aeruginosa. Placing the microbes in petri dishes with tasty bacteria food, the researchers let the microbes evolve, took samples after 24 hours, and let the sampled microbes start their own colonies. Within days, the strains had evolved into "hyperswarmers" that were incredibly fast at fanning out to find new food. The bacteria evolved extra tails (microbes in the original strain were single-tailed), thanks to mutations in a gene known as FleN. But not all the new bacterial strains were the same; the scientists identified three different types of tail configuration. The evolution in these bacteria was swift and unmistakable, but apparently came at a cost. Another ability P. aeruginosa needs to thrive is the ability to build a film over the colony — something that has made fighting infections from this bug very difficult. And when it comes to film building, single-tailed bacteria out-compete the multi-tailed fast movers.
Besides the DNA overlap with apes, some of the strongest evidence for evolution comes from our own species. Humans long believed ourselves to be the highest form of life on earth, made in the image of God. If so, our perfection needs a little work. Some of us have flat feet, heel spurs, and ankles prone to recurring sprains. Some of us have cracked vertebrae and slipped disks — unfortunate results of upending a spine that had long been horizontal in four-legged animals. Women got an especially raw deal: hips so wide they place extra strain on knees, yet not wide enough to make childbirth to those big-brained babies the least bit easy.
Human brains can pose problems at both the beginning and the ending of life. We are more intelligent than our ape relatives, but at a price. A study published in 2015 suggests that the same genes responsible for increased neuron connectivity may also lead to Alzheimer's — a condition not known to afflict any other animal, not even great apes.
Ever suffered from the hiccups? Thank the convoluted path that nerves must follow between your brain stem and your diaphragm; in fish, those nerves enjoy a less troublesome route. We humans have appendices, perhaps useful to our ancestors, but in us useless leftovers that occasionally inflame and rupture. Before the invention of surgery and the adoption of surgical hygiene, your own appendix could easily kill you.
Again, why did evolution do these annoying things? Because evolution doesn't have to be perfect, it merely has to be effective. It only has to be good enough to give you sufficient time to pass on your genes.
Think you picked up your fear of snakes from your skittish relatives? Maybe not. Two studies published in 2013 suggested that the way humans recoil from a coiled legless reptile may have been shaped by natural selection. One study examined the ability of children to rapidly spot snakes in photographs. Not only did the kids find the snakes with the same speed as adults, but the aptitude for identifying the reptiles was just as strong in city-dwelling kids who had likely not seen snakes outside of a zoo. Later in the year, a study of macaque monkeys used electrodes wired through the primates' brains to observe the firing of neurons in response to pictures of geometric shapes, monkey hands, monkey faces and snakes. Dozens of neurons that showed no response to the shapes or monkey parts fired strongly in response to the reptiles. Snakes probably counted among the deadliest threats to our primate ancestors, and that tough environment would have favored a brain able to identify such slithering dangers quickly.
Today, benefited by shelter, sterile surgeries, antibiotics, vaccines, car ownership and convenience stores, we humans in the developed world must cope with new dangers: diabetes and obesity. Our bodies — better adapted to a hunter-gatherer world where calories were scarce and exercise was abundant, where our bodies had to store fat to get us through long spells of little or no food — don't deal so well with the modern glut of cheeseburgers, bourbon and Twinkies. Today, overweight people outnumber underweight people the world over.
The mismatch between our hunter-gatherer bodies and modern diets is also apparent in dental health — or lack of it. Many of us harbor painful memories of wisdom tooth extraction, made necessary by jaws less robust than our ancestors'. (While many of us gave our third molars to our dentists, some populations have largely dispensed with those bothersome extra teeth. One study concluded that prehistoric people of Mexico had no wisdom teeth, and another study found 25 percent of Mexico's current population missing at least one wisdom tooth.) Besides more robust jaws, ancient humans had far fewer cavities. Studies of thousands of fossil humans found cavities in less than 2 percent of them. That began to change with the advent of farming and the consumption of cereal, but the problem got far worse with the introduction of affordable sugar within the last few centuries.
Studies of different human populations indicate that human evolution continued not only after we branched off from apes, but even long after Paleolithic times. People whose ancestors came from warm, lowland environments, who had to work hard for all their meals even after food became abundant elsewhere, tend to have slow metabolisms. People whose ancestors came from cold, highland environments tend to have high metabolisms. While one group had to survive long periods of famine, the other group likely had to metabolize lots of animal fat. What both groups have in common are lifestyle diseases in response to a modern Western diet and sedentary mode of living.
City life has apparently shaped human evolution, too. In centuries past — and in many parts of the world today — urban life has been tough, thanks to cramped and dirty living conditions. As a result, cities and tuberculosis go way back. Surviving such challenges over the long haul has entailed evolving resistance to the disease. A study published in 2010 correlated a genetic makeup that confers a resistance to tuberculosis and a few other maladies with a long duration of urban settlements. Iranians and Turks living around ancient cities had high resistance; Sami (or Saami) and Malawians living in places that weren't urbanized before the late 19th century had much lower resistance.
Evolution of other organisms plays a role in human healthcare. Since humans learned about antibiotics, we've used them to fight infection, but we haven't always enjoyed the results we wanted. Staphylococcus (staph infection) evolved a resistance to Penicillin in 1946, to Methicillin in 1961, to Vancomycin in 1986, and to Zyvox in 1999. Growing resistance of hospital "superbugs" to antibiotics spread across six European Union nations between October 2010 and March 2011. Meanwhile, the HIV virus evolves so quickly that multiple species can thrive in a single patient. On these fronts, at least, evolution appears to be working against us.
When Darwin wrote The Origin of Species, he lamented the incompleteness of the fossil record. His friend T.H. Huxley disagreed, stating, "The primary and direct evidence in favor of evolution can be furnished only by paleontology. . . . if evolution has taken place, there will its mark be left; if it has not taken place, there will lie its refutation." In a way, both men were right.
To become a fossil, you have to be buried soon after you die — before weather or scavengers destroy your remains. The dirt and mud burying you then have to harden sufficiently to protect what's left of you over thousands or more likely millions of years. At some point, your remains have to find their way to the ground surface and erode out. And there's no guarantee that when your fossilized self sees the sun again that some human — let alone a human who knows or cares about fossils — will happen along at the right moment to find you. In other words, the odds of becoming a fossil are slim. The odds of being found as a fossil are slimmer still.
So the fossil record is spotty at best, but even with so many pieces missing, it tells us quite a bit about the history of life on earth, and more discoveries happen all the time.
One of the most important ways in which the rock record supports evolutionary theory is the succession of fossils in older versus newer rock layers. As far back as the 18th century, scholars realized that fossils in older layers differed more from modern life forms than fossils in newer layers. While many fossils from the Pleistocene Ice Age resemble organisms living today, far fewer fossils from the Age of Reptiles do. If you venture back in the rock record to the Precambrian (prior to roughly 550 million years ago), you'll find few fossils of multicellular organisms at all. So striking has this fossil succession been that when asked what would disprove evolution, 20th-century British scientist J.B.S. Haldane quipped, "Fossil rabbits in the Precambrian." No such bunnies have ever been found.
Fossils that have been found in great abundance date back to the Cambrian, starting about 545 million years ago. Fossil lovers have collected trilobites for centuries. Naturalist Edward Lhwyd published a description of a "flatfish" in 1679. In the Victorian era, a well-polished trilobite was mounted in a gold pin known as the Dudley Locust Brooch, now on display at the Natural History Museum, London. Trilobite fossils vary so much in size that some are best measured in millimeters while others are better measured in feet. Some sport spines, others have eyes on the ends of stalks. Yet these ancient water bugs remain recognizable as trilobites thanks to their shared body plan: horizontal segments spanning three lengthwise sections. No matter how big and fancy some of them got, they shared the same ancestral shape.
Thousands of trilobite species evolved during the Paleozoic Era, the last of them dying out around 250 million years ago. Paleontologists have traced some of their more exuberant decorations to the evolution of more rapacious trilobite predators. Some trilobites evolved spikes to puncture would-be diners while others burrowed under the sea floor and left just the tips of their stalk eyes at the surface. Recent research has traced the evolution of another defensive feature. Trilobites could roll up like a modern-day pill bug or armadillo. A 2013 study found that this useful posture evolved early on in trilobite history, though enrollment tricks got more sophisticated over time. Early trilobites had to maintain their rolled-up posture through muscular effort; later trilobites came outfitted with body parts that fit together like locks, frustrating bigger animals trying to pry the bugs open. Other researchers have found similarities between the features of ancient trilobite eyes and the peepers of modern horseshoe crabs — "a 'living fossil,' which probably retained this ancient basal system successfully until today."
One argument raised about the fossil record is that it has no transitional forms. Yet two of the earliest, most famous fossils ever found were stunning examples of transitional fossils. In 1860, the limestone quarry in Solnhofen, Germany, yielded a fossil feather. A year later, the same quarry gave up a better prize: a partial skeleton of Archaeopteryx lithographica. Sir Richard Owen, in all fairness a brilliant comparative anatomist, described the fossil as "unequivocally a bird" and suggested that, if the whole creature were found, it would look like a modern bird. It certainly wouldn't have any teeth. In 1877, a complete specimen was found at Solnhofen, and this fossil sported a toothy grin to refute Owen's prediction. It was a lizard- and bird-like fossil.
Although itself a transitional fossil, Archaeopteryx followed millions of years of dinosaur miniaturization. A study published in 2014 examined 120 taxa and 1,549 skeletal characteristics of dinosaur fossils from the Jurassic and Cretaceous. The authors found that the ancient reptiles underwent about 50 million years of size reduction before Archaeopteryx. The authors hypothesized that shrinking size might have been driven by bird ancestors taking up residence in trees, perhaps to avoid predators on the ground. Life in trees favors small size and low weight, and the process may have prompted other traits: big eyes and big brains for negotiating in a three-dimensional environment (as opposed to two-dimensional environment on the ground), and feathers for insulation.
The small, carnivorous reptiles that evolved into birds starting about 150 million years ago diverged into two groups. Ornithuromorphs gave rise to modern birds. Enantiornithines, also called "opposite birds," had shoulder joints that connected in reverse compared to those of ornithuromorphs. Like Archaeopteryx, they had teeth, and they also had clawed wings. Paleontologists surmise that the opposite birds were poor fliers compared to the ancestors of modern birds, but these animals mixing reptilian and avian characteristics managed to last millions of years before going extinct at the same time as dinosaurs.
Ichthyostega, Acanthostega and Tiktaalik provide more examples of transitional fossils left by fish slowly transmogrifying into landlubbing tetrapods. Transitional forms also document the mammalian return to water. Paleontologist Phil Gingerich was overjoyed to find a whale ancestor, Rodhocetus, in Pakistan. Years earlier, he had been disappointed to find a fairly pedestrian fossil whale ancestor, Basilosaurus, in the same region. Yet he perked up considerably when he found the creature's diminutive legs. Why hadn't anybody found its legs before? Because nobody had looked. Why had nobody looked? "Because whales don't have legs!" Years later, Gingerich found fossils of the whale species Maiacetus inuus, including a pregnant mother. The whales' teeth were well-suited to a diet of fish, but the fetus was positioned head-down, characteristic of life on land. Together, the fossils indicated another transitional form — a whale that lived most of its life in the sea, but had to return to land to give birth. Whale fossils have shown us other examples of change. Today's sperm whales lack upper teeth and rely on suction to partake of their prey, but in 2010, paleontologists described the skull of a gigantic, 12 to 13 million-year-old sperm whale whose lower and upper jaws sported teeth resembling steak knives.
In the Middle Ages and Renaissance everybody just knew you could leave some wheat and old rags in a warm spot in your barn and make mice in a single day. Over time, naturalists restricted this assumption to only lowly creatures like insects, and later microbes. In the 19th century, Louis Pasteur established that even microscopic life couldn't spontaneously arise from decaying matter (a process known as heterogenesis).
Don't Pasteur's findings make abiogenesis — a term coined by Huxley to mean life arising from non-life (what must have happened on early earth) — impossible? Well, no. Pasteur only established what has become common knowledge about life as it exists on earth today. On a young earth, the environment was very different. For starters, the atmosphere lacked oxygen — a gas that would have poisoned most of the earliest life forms.
Understanding life's earliest history on earth requires understanding what life is, and the definition turns out to be tricky. In general, life reproduces itself and passes along traits, life maintains itself by changing energy and matter, and life has some physical boundary that separates itself from the outside world. But the border between life and non-life is surprisingly fuzzy. Viruses have genetic code and some other trappings of living cells, but must rely on their hosts to reproduce. Prions (the culprits spreading mad cow disease) are just proteins folded in a weird way. Even crystals can reproduce via cloning. None of these things fit the definition of life, but they skulk along the margins. They are not unusual. They have been around a long time, including billions of years ago, when our planet was young.
Some scientists suspect that the organic molecules that acted as life's building blocks may have synthesized in earth's early atmosphere and rained down onto the planet, or hitched rides on extraterrestrial bodies. In 1953, Stanley Miller and Harold Urey combined gases they believed common in the early atmosphere (water, methane, ammonia and hydrogen) and added electrical charges. Their experiments produced amino acids — not life, but impressive. A valid criticism of these experiments was that they didn't reflect a more modern understanding of earth's early atmosphere. We now understand that volcanic discharges (including carbon dioxide, nitrogen, hydrogen sulfide, sulfur dioxide and water) probably played a major role. But later experiments with more realistic gas configurations still produced results similar to Miller's, and recent studies suggest that earth's early atmosphere was probably quite conducive to producing pre-biotic compounds such as amino acids.
Charles Darwin speculated that life might have first arisen in a lukewarm pond, but a growing number of evolutionary biologists have envisioned something similar to hydrothermal vents on the sea floor. Those harsh environments are riddled with arsenic, and the abundance of a toxic chemical poses a problem for early evolution. The bulk of life on earth is composed of six elements: carbon, hydrogen, oxygen, nitrogen, sulfur and phosphorus. A study carried out at Mono Lake, California, and published in 2010 suggested that, under the right conditions, a bacterial strain known as GFAJ-1 could substitute arsenic for phosphorus to make biomolecules, including DNA. The study's findings have, however, been challenged by other specialists in the field and remain controversial.
Harsh environments used to be the norm on our planet. About 4 billion years ago, the solar system was young and conditions were violent, with giant chunks of rock careening into planets regularly. Our own moon may have been formed by one such impact. In 2014, a team of Czech scientists conducted an experiment to replicate the pressure-cooker conditions created by an asteroid slamming into the earth. The researchers used a high-powered laser to blast a solution of formamide — a chemical that forms from the reaction of hydrogen cyanide and water, and was likely abundant in the early days of our planet. The experiment produced adenine, guanine, cytosine and uracil: the nucleobases of RNA. The experiment suggested that, rather than impeding the development of life, the violent impacts of our early solar system might have contributed to its formation.
But even with organic molecules handy, making cells isn't easy. Although simple compared to us, bacteria are complex. They can generate energy, eliminate waste, wriggle around and reproduce. The evolution of single-celled organisms required intermediary steps, and three scenarios enjoy serious consideration today. One scenario is that metabolism came first; simple molecules powered by chemical energy from minerals preceded genetic material. Another scenario is the RNA World; perhaps given a helping hand by clays or certain types of carbon-based compounds, genetic molecules began self-replicating. This hypothesis has been bolstered by findings that RNA can store genetic information, copy itself, and even carry out metabolic functions. The third scenario is some kind of collaboration between metabolism and genetics.
Building on the RNA World in 2009, researchers led by John Sutherland of the University of Cambridge reported that reactions of relatively simple compounds (acetylene and formaldehyde) could produce two of the four nucleotides needed to build RNA. Six years later, Sutherland's team found that RNA could be created by a sequence of reactions of even simpler precursors: hydrogen cyanide, hydrogen sulfide and ultraviolet light. Even better, the same sequence of reactions could make the precursors of amino acids and lipids. The research helped resolve a conundrum that long vexed biologists: The genetic materials needed to make proteins also depended on those proteins, and everything needed lipids. This research indicated that all three components could have been created in a relatively short time. Sutherland's team argued that our planet's nascent environment would have provided the hydrogen cyanide, hydrogen sulfide and ultraviolet light necessary to start the process, but cautioned that the reactions would require different catalysts and probably wouldn't happen in the same place. They might, however, have been washed into a warm Darwinian pool by rainwater.
However they arose, replicating molecules likely took eventual refuge inside membranes. Just as your skin protects your insides from the outside world, a membrane would provide advantages over braving the cold, hard world completely naked. Besides growing protective layer, single-celled organisms may have also gobbled and enslaved other single-celled organisms to do their grunt work. Both the gobblers and the gobbled benefited. These gobbled-up parts would become organelles — and would enjoy some protection from the outside environment inside the larger cells. Like organs in your body — stomach, liver, lungs — do certain jobs, organelles would carry out specialized tasks, too. Some types of organelles today have double membranes, apparent remnants of the swallowed cell's original membrane plus the membrane of the bigger cell that ate it. And all the while, everybody probably swapped genetic material like MP3 files.
Biologists have divided life on earth into three domains: archaea, bacteria, and eukaryotes (this last category includes us). Lynn Margulis found that mitochondria — eukaryotic cells' power generators — sport genes more like those of bacteria than eukaryotes. Meanwhile, Carl Woese and his colleagues found that archaea (single-celled organisms that sometimes occur in extreme environments) share more genetic material with eukaryotes than bacteria. A study published in 2015 identified Lokiarchaeota, a type of archaea excavated from beneath the Atlantic Ocean that shares more genes with eukaryotes than any other known archaea. Lokiarchaeota, the researchers found, has the same genes that build compartments inside eukaryote cells, and construct and destroy eukaryote "skeletons." The newly discovered type of archaea also has genes indicating that it could gobble up microbes and perhaps even turn some of those microbes into organelles.
In simplistic terms, the archaean parts of our cells primarily process information while the bacterial parts mostly handle housekeeping, though the division of labor isn't strict. The common ancestor of today's life may have really been all the microbes on young earth.
How could we wind up with genetic material from different domains? It could be that, when life was young, RNA and DNA didn't have much competence in self-replication, and mutations ran rampant. Genetic replication eventually improved. Likewise, if cell membranes became more sophisticated, they would get better at keeping out intruders (including genes). So the lateral gene transfer that was once commonplace, and still occurs in bacteria today, has probably become much rarer in multicellular organisms. In short, not only has life evolved, evolution has evolved.
Single-celled organisms still thrive all over our planet today, but well over half a billion years ago, some of them began organizing into multicellular colonies, the likely forerunners of multicellular life forms. A study published at the beginning of 2012, using common brewer's yeast, found that this process can happen surprisingly quickly. Not only did yeast cells organize into snowflake-like clusters, but after many generations, some of the cells in those clusters evolved higher rates of programmed cell death, known as apoptosis, a process that facilitates offspring separating from the "parent" cluster.
Even after decades of research, however, most of the puzzle pieces of the earliest life on earth still elude us. We may never find them. Billions of years of geologic processes and the planet-transforming power of life itself have probably wiped away many clues. But although the mysteries of earth's early life forms are big, research continues.
A few billion years after life first evolved on earth, a species on our planet grew intelligent enough to wonder about the past. No part of the story of evolution has aroused stronger emotions than the human story.
Naturalists began uncovering fossil humans before Darwin published On the Origin of Species. The first fossil human that naturalists found was perhaps the Red Lady of Paviland, identified by William Buckland in the 1820s. "Red" reflected the fact that the body was covered with red ochre, but Buckland misfired a bit; the skeleton belonged to a man. That fossil, though ancient, wasn't really a different kind of human. But in 1856, quarry workers found truly puzzling human remains in the Neander Valley, and Johann Fuhlrott and Hermann Schaaffhausen realized these remains belonged to someone quite different from modern Europeans.
Writing about human evolution, the 19th-century naturalist Ernst Haeckel confidently asserted that our evolution consisted of precisely 22 phases, and the 21st was a yet-to-be-identified "missing link." If Haeckel predicted the missing link, Eugène Dubois arguably found it, and he found it far from his European homeland. In Indonesia he oversaw the discovery of Pithecanthropus erectus, now known as Homo erectus in the 1890s. Returning home to Europe, Dubois expected a more enthusiastic reception than he got. His personality was likely part of his problem, but perhaps European scientists just weren't ready for a non-European ancestor. Decades later, Raymond Dart suffered similar disillusionment when his description of the Taung Child (Australopithecus africanus) aroused mostly scorn. (Dart's find conflicted with what some early 20th-century anthropologists thought they knew about Piltdown Man, not debunked until 1953.) Mary and Louis Leakey had better luck in the latter half of the 20th century, and Donald Johanson's 1974 discovery of Lucy captivated the public, at least the part of the public that accepted evolution.
But discoveries of fossil hominids — now often referred to by the more specific term "hominin" — didn't occur in the same order as the hominins themselves. So let's start at the beginning of the human story, at least the beginning of what we understand today.
During the Miocene Epoch, from about 23.5 million years ago to 5.3 million years ago, rainforests covered huge expanses of our planet, much bigger areas than forests occupy now. Forests make good primate habitat, and the number of primate species alive during the Miocene likely dwarfed the number of primate species alive today. Toward the end of that geologic time period, an apelike species apparently evolved into an upright-walking form that would eventually give rise to people.
As of late 2013, the three leading contenders to the earliest hominin title included Orrorin tugenensis, Sahelanthropus tchadensis, and Ardipithecus kadabba. All three fossils have been dated at somewhere between 5 million and 7 million years old. Orrorin and Ardipithecus turned up in eastern Africa, the same general region as many other hominin fossils. Sahelanthropus was unusual in that it was found in central Africa. The respective discovery teams have advanced competing arguments for their finds as the earliest known hominin, and naturally they don't totally agree with each other. But paleoanthropologists agree that two characteristics of human ancestors include bipedalism (walking on two feet), and reduced canines. Bipedalism is fairly self explanatory, although it's important to understand that early hominins may have had a very different gait than ours. Canines might need a little more explanation.
If a dog has ever snarled at you, you might have noticed its fangs, which can look menacing even in a dainty, purse-sized dog. In most, though not all, species of non-human primates, the males also have big canines. These males often fight with each other for girlfriends by showing their teeth or, worse, using them. Outside of vampire stories, humans have small canines, and one of the early signs of human ancestry is a reduction in canine size. Darwin suggested that human ancestors lost their need for big canines because walking upright freed their hands to carry weapons, and they could clobber each other instead. A more commonly accepted hypothesis today is that those free hands enabled males to bring their sweethearts useful things like food, and the ladies wisely favored the sensible, provisioning males over the hotheads. Either way, smaller canines won the evolutionary battle in hominin teeth.
Led by Tim White, the research team that identified Ardipithecus kadabba as a candidate for earliest hominin also proposed it was the ancestor of a later member of that genus: Ardipithecus ramidus. Dated at about 4.4 million years old, this species, nicknamed Ardi, showed signs of tree climbing — including an opposable toe — and bipedalism — evidenced by hip and leg bones. But Ardi held a surprise for the science community; the fossil was strangely unlike a chimpanzee. Ardi served as a reminder that, like humans, chimps have continued evolving away from our last common ancestor too.
Ardipithecus was followed by the genus Australopithecus, including Australopithecus anamensis, Australopithecus afarensis and Australopithecus africanus, to name just a few. The small-brained, bipedal Lucy (A. afarensis) received widespread attention in the mid-1970s, and in the late 1970s, a research team led by Mary Leakey uncovered australopithecine footprints preserved in volcanic ash at Laetoli, Tanzania. Australopithecines showed evidence of tree-climbing, but also walked upright.
Many anthropologists point out that what matters as much as our intelligence is our ability to manipulate our surroundings, in other words, our hands and opposable thumbs. A study published at the beginning of 2015 compared metacarpals (the bones forming the base of the thumb and the palm of the hand) from modern humans, modern apes, Neanderthals, early Homo sapiens and Australopithecus africanus. The researchers concluded that the australopithecine bones showed evidence of the same forceful precision grip as that employed by humans — australopithecines could squeeze things. The findings implied tool use among hominins about half a million years earlier than previously thought. In April 2015, researchers announced the discovery of tools at Lomekwi, Kenya. Found in 2011, the tools included a core and corresponding, snugly fitting rock flake. The researchers estimated the tools to be 3.3 million years old.
Fossils indicate that australopithecines came in two general varieties: gracile and robust. Gracile australopithecines probably led to our own genus, Homo, while the robust australopithecines constituted a side branch of the hominin evolutionary tree. Adapted to chewing extremely coarse, tough plants (or simply to chewing a lot), some robust australopithecine species sported molars as big around as a nickel or even a quarter.
Our own ancestors took a different approach to food, which included eating meat and eventually processing food through cooking and/or grinding it before sitting down to dine. Meat eating has been linked to bigger brains by the expensive-tissue hypothesis. Digesting meat doesn't take as much intestinal yardage as digesting leaves, so an animal that survives on a meaty diet can get by with a smaller gut. Both the brain and the digestive tract require a lot of energy, and this hypothesis argues that there has been a tradeoff between brain size and gut size, with meat eating facilitating bigger brains. This presents a chicken-and-egg conundrum since we can't be sure which — meaty diets or bigger brains — came first. Whichever came first, bigger brains are a characteristic of the genus Homo, although traits associated with this genus (long legs, reduced size differences between the sexes, and energy-hogging brains) probably didn't all arise at the same time.
Paleoanthropologists estimate that australopithecines evolved into early forms of the genus Homo sometime between 3 million and 2.5 million years ago, but verifying this hypothesis has been complicated by a dearth of early Homo fossils. A 2.3 million-year-old maxilla (upper jaw) long served as the oldest example of the genus, and the type specimen for Homo habilis, or "handy man," is younger still. But studies published in Science and Nature in early March 2015 shed new light on the earliest members of our species, including a computerized reconstruction of the mandible (lower jaw) from the Homo habilis type specimen, and the find of a brand new mandible from Ethiopia. The authors found that the jaw mingled australopithecine characteristics with traits of our own genus. Comparison of the Homo fossils from this period suggested to the researchers in these studies "an evolutionary explosion at the dawn of our genus," according to Nature.
Over the lifetime of the genus, paleoanthropologists have identified multiple Homo species, and one of them, Homo erectus, thrived not only in Africa, but also in Eurasia. Remember that Dubois found the first known example of this species in Indonesia. Another famous example of this species, Peking Man, went missing during World War II.
One of the most complete fossils in the hominin record is a juvenile Homo erectus skeleton found at Nariokotome, Kenya. Estimated to be seven or eight years old at death (but equivalent to an 11- to 13-year-old modern human), Nariokotome Boy (or Turkana Boy) was already over 5 feet tall. If his lived-out future included an adolescent growth spurt, then he would have become a tall man. But significant height might not have been a characteristic of Homo erectus so much as a trait Homo erectus living in the tropics. An especially rich fossil site at Dmanisi, Georgia, is the oldest Homo erectus site outside Africa, and it has preserved the remains of multiple individuals. Dated at around 1.8 million years old, the site shows remarkable variation among hominins living within a short (geologically speaking) time span. Skull size, brain size, and skeleton size all show wide disparities, suggesting that this was simply an extremely diverse species. In fact, a 2013 study on Dmanisi led by David Lordkipanidze argued that hominin species identified from other sites as well — Homo erectus, Homo habilis and Homo rudolfensis — were all one species with a lot of variability.
Besides variability, Homo erectus fossils show something else: evidence of kindness. One of the fossils from Dmanisi is toothless. If you're toothless long enough (and don't starve), your jaw changes, eventually converting those lumpy tooth sockets to smooth bone. But if you lost all your teeth at Dmanisi, you couldn't get dentures. The owner of the toothless jaw may have had his or her food chewed by a family member or (very good) friend. Likewise, a Homo erectus female fossil from Africa is covered by bone that looks like it was woven. The deposition of such weird bone is characteristic of Vitamin A poisoning. This toxic condition, which has sometimes struck Antarctic explorers, results from eating too much carnivore liver, and it is exquisitely painful. If you were fending for yourself on the African savanna, you'd die long before the disease progressed as far as it did in this woman. For her to survive as long as she did meant that someone looked after her near the end.
Homo erectus survived as a species for well over 1.5 million years, and before they completely died out, a new species evolved that has figured large in our understanding of human evolution. Homo neanderthalensis arose in Eurasia about 200,000 years ago, although hominins with proto-Neanderthal characteristics may have arisen hundreds of thousands of years earlier. (Spain's Sima de los Huesos Cave, a site preserving thousands of fossils, includes many complete hominin skeletons. A study published in 2014 argued that those fossils, dating from about 430,000 years ago, display Neanderthal facial features, though other Neanderthal characteristics such as large brain size evolved later.)
Neanderthals have a tortured history in anthropology, identified as diseased modern humans then identified as stooped and awkward because the scientist making that determination examined a Neanderthal riddled with arthritis. One of the early claims made about Neanderthals, that they buried their dead, has been alternately challenged and vindicated. Like Homo erectus, Neanderthal fossils preserve evidence of people who must have been looked after by others. Finds associated with Neanderthal remains suggest symbolic behavior. Near Krapina, Croatia, 130,000-year-old eagle talons from a Neanderthal site bear cut marks and abrasion marks that might have resulted from their use in necklaces. And Neanderthals apparently admired fossils, or at least the animals that would become fossils. A hand axe from Norfolk, England, perhaps dating to 200,000 years ago, has been fashioned to give special prominence to a bivalve shell. (Even more remarkable is an even older hand axe, perhaps the handiwork of Homo heidelbergensis, that shows off a fossil sea urchin.)
Early 20th-century scientists such as Henry Fairfield Osborn considered Neanderthals direct human ancestors. That view no longer predominates. Instead, Neanderthals coexisted with direct ancestors of modern humans, who evolved in Africa. The most likely path out of Africa is through the Middle East, and Neanderthal and Homo sapiens were living in close proximity to each other about 55,000 years ago. But Neanderthals haven't been completely kicked out of the family tree; genetic studies indicate that people with ancestry outside of Africa carry small percentages of Neanderthal DNA. Neanderthals apparently interbred with ancestors of some modern humans.
One piece evidence of this interbreeding comes from a roughly 40,000-year-old modern human jawbone from Pestera cu Oase Cave in Romania. In 2015, Erik Trinkaus announced that DNA analysis of the fossil showed "large chunks" of Neanderthal DNA. Over generations, any one person's genetic material gets broken up into smaller and smaller pieces. The long stretches of uninterrupted Neanderthal DNA — one of which spanned the half length of chromosome 12 — indicate that the Neanderthal ancestor was only four to six generations back. In other words, the mandible apparently belonged to the great-great-great-grandson of a Neanderthal.
Two studies published early in 2014 found that — although descendants of Europeans, East Asians and other populations outside of Africa owe about 2 percent of their DNA to Neanderthals — a far greater percentage of the Neanderthal genome has been preserved in modern populations because different people carry different genes. Some of those genes relate to hair and skin color, and to diseases such as lupus and diabetes. But the studies also found that Neanderthals and the ancestors of modern humans were "at the edge of biological compatibility," and their hybrid progeny may have eventually become infertile.
Neanderthals are fascinating, long considered "another way of being human," but it's important to view them in their proper perspective, particularly in light of recent DNA studies. In the autumn of 2013, Adam Van Arsdale, anthropology professor at Wellesley College and longtime researcher at Dmanisi Cave, explained to students of Wellesley's massive open online course (MOOC) on human evolution:
In the history of paleoanthropology, Neanderthals are central. A lot of our earliest fossil evidence for human evolution comes in the form of Neanderthals . . . And yet in an evolutionary standpoint, Neanderthals probably aren't as important as the attention we give them. If we think about the evolutionary reality of humans for the last million and half years, as they've occupied large stretches of Africa, the Middle East, East Asia, Southeast Asia, Europe was probably always fairly marginal, on the peripheries of that environment. Europe was one of the last areas of the Old World to be occupied. And throughout the late Pleistocene, as we had major ice age events, it became an even smaller space, as populations where restricted to Southern Europe. So Neanderthals were probably always a fairly small population, probably only a tenth the size of the population in Africa, maybe even less. . . . But they're important in the history our discipline because they've been the center of discussion for so long.
Perhaps no place better illustrates Europe's shrinking and growing human habitat than the United Kingdom. Human occupation of Britain extends back at least 800,000 years, evidenced in part by a hominin trackway — the oldest so far found outside Africa — exposed at Happisburgh by violent storms in May 2013. Yet at various times since, the region was probably entirely abandoned by humans. Thank climate swings and glaciers.
Except for earth's earliest days, the amount of water at the planet surface has been pretty finite. That means that — as more water has resided inside glaciers during ice ages, including the recurring ice ages of the Pleistocene epoch (roughly 1.6 million to 10,000 years ago) — global ocean level has fallen. What is today the island of Britain was once a peninsula of northwestern Eurasia. Geologists surmise that during the Pleistocene, a lake at the tip of a glacier eventually broke through the chalky spine connecting Britain with mainland Europe and, as ocean level rose, water isolated the landmass. The same conditions that would have lowered sea level enough to reconnect Britain to the rest of Eurasia also covered the area in ice, making it an extremely uninviting habitat.
As it did in Britain, lower sea level during the Pleistocene expanded habitable area on around modern-day Taiwan. While pulling in a fishing net off the west coast of Taiwan, fishermen found a robust human mandible. A study released in early 2015 estimated the fossil's age at somewhere between 10,000 and 190,000 years (it's hard to pin down dates for fossils dredged off the seafloor). The researchers were cautious about identifying the species, but suggested it might belong to an as-yet unclassified species.
Through these climate shifts that often made Europe unattractive, Africa provided a much greater habitable area. The researchers involved in the Neanderthal DNA studies published in early 2014 agreed that the ancestors of modern Africans likely also interbred with archaic human populations that are now extinct, and that future studies should look for evidence of those groups. The task could be daunting, though. Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology, overseer of research teams that conducted study after study of ancient human genes, remarks that Africa's greater human genetic variation could make genetic contributions from archaic populations harder, not easier, to detect than in Europe.
In 2010, the Natural History Museum at the Smithsonian opened its state-of-the-art, awesome hall of human origins. Within weeks, a new study led by Pääbo described a previously unknown hominin species from Denisova Cave in Siberia. Dubbed Denisovans, these enigmatic humans were identified from DNA analysis of fossils too fragmentary to give any idea of what the hominins looked like, but they apparently lived at the same time as Neanderthals and the direct ancestors of modern humans. Considering the fossils turned up in Russia, you might expect Denisovan DNA to occur in large parts of Russia and China, but it has proven relatively scarce in modern human populations outside of Southeast Asia.
Ongoing DNA studies present an increasingly complicated picture of human history. In rapid succession, two 2013 studies found that (1) Denisovans bred with Neanderthals, ancestors of people now living in East Asia and Oceania, and another group of extinct archaic humans who were genetically dissimilar to both Neanderthals and modern humans, and (2) Mitochondrial DNA (inherited through females) from Sima de los Huesos Cave showed a link to Denisovans. Ancient Eurasian hominin DNA also showed evidence of inbreeding, perhaps a common event when local populations were isolated by a tough environment. In short, early humans were a randy bunch. Given the varying levels of Denisovan DNA in modern populations, Pääbo suggests that early migrants out of Africa might have met Denisovans while traveling along the coast of southern Asia.
The following year, a new study concluded that "Denisovan-like" DNA gave some modern humans an adaptive edge. Tibetans able to breathe easily at high altitudes have a special version of a gene known as EPAS1. The "superathlete" version of this gene lets Tibetans make effective use of small amounts of oxygen typical at high altitudes. Comparisons between populations around the world and between modern and Denisovan DNA indicate that modern Tibetans likely inherited the useful version of the gene from Denisovans at some point in the last 40,000 years or so. The researchers remark, "With our increased understanding that human evolution has involved a substantial amount of gene flow from various archaic species, we are now also starting to understand that adaptation to local environments may have been facilitated by gene flow from other hominins that may already have been adapted to those environments."
In the capacity to amaze, nothing tops the 2004 announcement from Peter Brown, Mike Morwood and their colleagues about an 18,000-year-old, 1-meter-tall "hobbit," Homo floresiensis, on the Indonesian island of Flores. Controversy raged around the hobbits, with some alleging the hominins were malformed, little-brained midgets, but braincase scans suggested otherwise. Although certainly not an ancestor of modern humans, the hobbits appeared to be a different species of human that had coexisted with anatomically modern humans for thousands of years.
Homo floresiensis puzzles paleoanthropologists for a few reasons. For starters, even when Pleistocene glaciers locked up maximum amounts of water and ocean levels were at their lowest, you couldn't get to Flores without an ocean voyage. It's possible their ancestors (un)willingly rode rafts of vegetation, perhaps in the wake of a tsunami. The hominins who became the hobbits may have evolved in isolation for some 800,000 years. But just who were those ancestors? Some hobbit features appear even more primitive than those of Homo erectus. The tremendous variability at Dmanisi provides a possible explanation for the unusual features of Homo floresiensis, but this remains an area of research and debate.
We can only wonder whether the hobbits ever encountered their much larger evolutionary cousins. Paleoartist John Gurche, who produced hominin reconstructions for the Smithsonian's new human origins hall, speculates about the most complete hobbit specimen, a female he's nicknamed Flo:
What expression would be fitting for Flo if she were able to see us? What would she have thought of our kind? I didn't have to think too hard about this one. We Homo sapiens do not have a good record when it comes to how we treat people different from ourselves. If she had any knowledge of our kind (and she may have, as modern humans were in the region during her time) we might have seemed to her like a race of violent giants.
Flores hobbits, like the Neanderthals and Denisovans, are extinct today, though Neanderthals and Denisovans have left some traces in modern populations. But the majority of our ancestry lies in Africa, from which multiple waves of hominin migrations began. Paleoanthropologists generally agree that modern humans derive most of our ancestry from a population that was living in Africa long after Homo erectus settled parts of Eurasia. In fact the majority of genetic variation in modern humans can be found not between African and other populations but within Africa, and this has always been the case with humans.
At various times in the hominin past, multiple species of humans lived on this planet. No so today. Now humans are all one species. And we all have ancestors from Africa.
Yet many questions remain, and new fossils, such as the hobbit and the Denisovan finger bone, often raise more questions than answers. We still don't know just when our ancestors developed language, or what proto-languages might have proliferated in the past. We can infer, but don't precisely know, what migration paths ancient humans followed.
Among the most significant developments in human evolution, Adam Van Arsdale identifies bipedality, the evolution of bigger brains compared to earlier hominins, and the adoption of agriculture. Two studies released online at the end of 2014 linked the adoption of agriculture to the evolution of lighter and unfortunately weaker joints in the human skeleton. In particular, the research found lower density in trabecular bone — the spongy tissue at the ends of bones such as the femur. The lower bone density likely evolved about 12,000 years ago, consistent with the development of the earliest farming.
While many paleoanthropologists agree with Van Arsdale's assessment of the most important events, others might choose different things. At a 2014 symposium at the Salk Institute for Biological Studies, anthropologists discussed what they termed "human self-domestication," highlighting shortened faces and diminished brow ridges over the past 80,000 years, and a drop in cranial capacity after the invention of agriculture. They likened traits in modern humans to those of some domesticated animals, including the retention of some juvenile physical traits in adults.
But while anthropologists may vigorously debate which traits matter most in defining modern humans, and precisely how human evolution occurred, they don't debate whether it occurred.
In 1925, Tennessee schoolteacher John Thomas Scopes was tried for teaching evolution, in violation of the recently enacted Butler Act. The act outlawed the teaching of "any theory that denies the story of the Divine Creation of man as taught in the Bible." The American Civil Liberties Union offered to defend anyone who defied the act, in hopes of overturning the law. Instead, Scopes's conviction was thrown out on a technicality, and the law remained on the books until the late 1960s.
In the decades following the Scopes Monkey Trial, quite a lot changed, yet some things remained very much the same. Teaching evolution is no longer illegal in the United States, but millions Americans still oppose the teaching of evolution in public school science classrooms. Of the world's industrialized nations, only Turkey's population shows greater opposition to evolutionary theory than the U.S. (In the Muslim world, support for creationism comes not from fundamentalists but, ironically, from relatively moderate clerics looking for a "middle way" between science and faith. One Muslim nation that appears to enjoy widespread support for evolution is Iran.)
The U.S. enjoys the rather unique distinction of politicizing evolution. During the 1990s, Republican Party platforms called for the teaching of "creation science" in Alaska, Iowa, Kansas, Oklahoma, Oregon, Missouri and Texas. In a New York Times editorial in 2005, moderate Republican, Episcopal minister and former senator John C. Danforth described the U.S. as the only country where a political party adopted a position on evolution. In June 2008, Governor Bobby Jindal signed into law the Louisiana Science Education Act singling out evolution (and global warming and human cloning) for what the act described as critical analysis. The move established something of a precedent. Between January 2004 and June 2013, state legislatures in the United States introduced 39 "academic freedom" bills that would open the door for creationism. Between January 2008 and June 2013, state legislatures introduced 15 bills targeting both evolution and climate change in public school science classrooms. Lawmakers in Tennessee, the same state that tried John Scopes, entertained legislation that would encourage "critical thinking" on the topics of "biological evolution, the chemical origins of life, global warming and human cloning."
In extreme cases, some Americans endorse the teaching of biblical literalism in public schools. Others push for the instruction of Intelligent Design. Still others want teachers to "teach the controversy."
A widespread public perception in the United States (and to a lesser degree in some other nations) is that scientists disagree about whether evolution is real. In October and November of 2001, Seattle-based think tank the Discovery Institute placed advertisements in The New York Review of Books, The New Republic, and The Weekly Standard. These ads featured a list of 100 PhDs (!) who "dissented from Darwinism." Members of the American public were understandably persuaded that a genuine controversy existed.
In February 2003, theoretical physicist Lawrence Krauss, a keynote speaker at the annual meeting of the American Association for the Advancement of Science, unveiled a response to the list of 100 PhDs. The National Center for Science Education (NCSE) had collected a list of 200 PhDs who agreed with the following statement:
Evolution is a vital, well-supported, unifying principle of the biological sciences, and the scientific evidence is overwhelmingly in favor of the idea that all living things share a common ancestry. Although there are legitimate debates about the patterns and processes of evolution, there is no serious scientific doubt that evolution occurred or that natural selection is a major mechanism in its occurrence. It is scientifically inappropriate and pedagogically irresponsible for creationist pseudoscience, including but not limited to "intelligent design," to be introduced into the science curricula of our nation's public schools.
Besides finding twice as many scientists as the Discovery Institute, NCSE added a further twist: In order to support the pro-evolution statement, evolutionists not only had to hold a PhD in science. They also had to be named Steve (or Steven, Stephen, Esteban, Stephanie, or some derivative). "Steve" was chosen for two reasons: in honor of the late Stephen Jay Gould, and because people named Steve or some variation comprise roughly 1 percent of the American population. So the Steve list could be multiplied by 100 to get a ballpark figure of how many scientists think evolution is real. Steves armed with PhDs have continued to sign up since February 2003. Steve number 300 was Stephen Hawking. On September 5, 2008, the Steve-o-Meter reached 900. On February 13, 2009, Steven P. Darwin — professor of ecology and evolutionary biology at Tulane University in New Orleans, although no relation to the most famous evolutionist — became Steve number 1,000. As of early November 2009, the Steve-o-Meter sat above 1,100. As of February 2015, it sat above 1,300.
So in comparing scientists with doubts about Darwin to scientists who accept evolution, the score isn't 100 to 200, or even 100 to 1,000. It's more like 100 to about 130,000. Project those percentages onto an election, and evolution wins by a landslide. As Joel Achenbach remarks in a National Geographic article on topics such as evolution, climate change and vaccinations, "There aren't really two sides to all these issues."
That's not to say there is no debate about evolution. Clearly there is. But it's a cultural debate, a religious debate and — given recent religious influence in American government — a political debate. But it's not a scientific debate.
In 2004, William Dembski wrote in The Design Revolution:
Intelligent design is not an evangelic Christian thing, or a generally Christian thing or even a generically theistic thing. . . . Intelligent design is an emerging scientific research program. Design theorists attempt to demonstrate its merits fair and square in the scientific world — without appealing to religious authority.
But in 1999, the very same guy had written in Intelligent Design: The Bridge Between Science and Theology:
[A]ny view of the sciences that leaves Christ out of the picture must be seen as fundamentally deficient. . . . [T]he conceptual soundness of a scientific theory cannot be maintained apart from Christ.
Intelligent design (ID) argues that many features found in living organisms are so complex, they must have been planned by an intelligent designer. A cornerstone of the argument is "irreducible complexity": some multi-faceted features simply could not have evolved by chance, and the removal of one part would collapse the whole system. Yet in a paper critiquing intelligent design, Elliot Sober observed that a horse with one, two or even three legs couldn't run very well, but horses didn't likely evolve one extra leg at a time. Appendages like four legs aren't controlled by four sets of genes, but by a single gene set that governs the development of appendages.
The leading think tank behind the intelligent design movement is the Discovery Institute in Seattle, Washington. In 2001, the institute's "Wedge Strategy" was leaked on the Internet. In part, it stated:
Design theory promises to reverse the stifling dominance of the materialist worldview, and to replace it with a science consonant with Christian and theistic convictions.
In 2005, intelligent design was put on trial in Dover, Pennsylvania, in 400 F.Supp.2d 707 (M.D. Pa. 2005). In the trial, as before, ID supporters insisted that they were promoting science, not religion. But one of the more interesting pieces of evidence offered by the plaintiffs was the straightforward substitution of "design proponents" for "creationists" in a textbook recommended to introduce intelligent design. Philosophy professor and long-time ID tracker Barbara Forrest examined successive versions of the book, Of Pandas and People, and found one substitution that went horribly awry: "cdesign proponentsists." Evolutionists described this sloppy substitution as the missing link between creationism and ID. On December 20, 2005, the presiding judge, John E. Jones III (a lifelong church-going Republican appointed by George W. Bush, it is worth noting) reached this conclusion about intelligent design:
Teaching intelligent design in public school biology classes violates the Establishment Clause of the First Amendment to the Constitution of the United States (and Article I, Section 3 of the Pennsylvania State Constitution) because intelligent design is not science and "cannot uncouple itself from its creationist, and thus religious, antecedents."
Much of the anxiety about evolution stems from the fear that, in accepting the theory, one denies the existence of God. In fact, evolutionary theory makes no demands about religious faith (or lack of it). People who accept evolution are free to draw their own conclusions about a higher power in the universe.
Although some evolutionists such as Richard Dawkins are atheists, other evolutionists, such as Kenneth Miller (biology professor at Brown University, and author of Finding Darwin's God) and Francis Collins (head of the National Human Genome Research Institute) see no conflict between evolutionary theory and religious belief. Mainstream Protestantism, Roman Catholicism, branches of Judaism and Islam all accept evolution.
Michael Zimmerman, evolutionary biologist and dean of the College of Letters and Science at the University of Wisconsin at Oshkosh, recently initiated a letter stating:
We the undersigned, Christian clergy from many different traditions, believe that the timeless truths of the Bible and the discoveries of modern science may comfortably coexist. We believe that the theory of evolution is a foundational scientific truth, one that has stood up to rigorous scrutiny and upon which much of human knowledge and achievement rests. To reject this truth or to treat it as "one theory among others" is to deliberately embrace scientific ignorance and transmit such ignorance to our children. We believe that among God's good gifts are human minds capable of critical thought and that the failure to fully employ this gift is a rejection of the will of our Creator.
Scientists acknowledge that there are some questions science simply cannot answer. Whether Genesis as recorded in the King James Bible describes a literal truth about the physical universe is a testable hypothesis, and it turns out to be false. We know this from dating of rocks and fossils, for one thing. But whether or not there is a God is not a testable hypothesis. That's a matter of personal belief. As Stephen Jay Gould put it, science and religion are "nonoverlapping magisteria." While evolution doesn't require a supreme being, it doesn't preclude the existence or involvement of such a being, either.
In a word: no. Although there's virtually no debate among scientists about whether evolution happens, they continue to debate how it happens. The story gets more intriguing every day.
Niles Eldredge co-founded the theory of punctuated equilibria (rapid bursts of evolution separated by long periods of little or no change) with Stephen Jay Gould in the early 1970s. He has since articulated a more comprehensive "sloshing bucket" theory of evolution, arguing that most evolution occurs in regional turnovers of species. A migrating sandbar on the ocean floor will decimate the bottom-feeders in its way, but the same kinds of animals will populate the sea floor in the sandbar's wake. But an asteroid hitting the earth is a complete game-changer. How hard the bucket of life gets kicked determines slosh size.
The more scientists examine life on earth, the more they unravel complex webs of interaction. For example, leafcutter ants feed on a certain type of fungus, and scientists long thought that leafcutter ants kept their fungal gardens pest-free with careful weeding. Then a graduate student discovered that the gardens were under continual threat from a different kind of fungus, a parasitic fungus. He also discovered that the worker ants' abdomens were covered with a substance commonly used in antibiotics. What had long looked like a simple partnership between two species (ants and the fungus they ate) was a more complicated relationship between four species (ants, their fungal food, an annoying fungal pest, and the built-in antibiotic).
Closer examination of genetics reveals more flexibility than once thought, too. This extra layer of complexity or flexibility in genetic material, nudged by factors such as lifestyle and stress, is known as epigenetics.
In August 2003, researchers at Duke University reported that the diet of a pregnant mouse mother could affect the functioning of her offspring's genes. By 2013, multiple studies had indicated that both exercise and diet could affect a process known as methylation. Methylation is the process in which assemblages of carbon and hydrogen atoms, or methyls, attach to either DNA or histones (the proteins around which DNA coils itself). It appears that DNA methylation switches off the gene while histone methylation enhances or inhibits gene expression. Methylation may alternately help or hinder a gene's ability to respond to other things happening in the body.
In 2014, another paper described the results of an ingenious study in which 23 healthy men and women were instructed to ride exercise bikes for 45 minutes four times a week for three months. The trick was that the study participants pedaled with only one leg, leaving the other leg at rest. The researchers then performed muscle biopsies on both legs. The biopsies showed more than 5,000 muscle genome sites with new methylation patterns — but only in the exercised legs, not the slacking legs. At least some of the genes with changed methyl groups had already been linked to muscle inflammation, metabolism or insulin response.
Although methylation patterns don't change DNA, they can apparently be inherited. Intriguing evidence comes from Holland where, in the winter of 1944, German blockades left the local population nearly starving. Babies conceived during the famine, known as "Hongerwinter," grew up to have a greater susceptibility to obesity and heart disease. Remarkably, so did their children. Studies of Hongerwinter baby genomes indicated that methylation had occurred in the genes connected to cholesterol and aging. Similar susceptibility to lifestyle disease has arisen in babies conceived during other famines, such as China's disastrous Great Leap Forward.
It may even be possible to uncover the effects of epigenetics in human ancestors. DNA degrades over time, but methylated DNA degrades differently from unmethylated DNA, and this finding allowed a team of international researchers to infer chemical tweaks to ancient genes in a 50,000-year-old Denisovan female and a somewhat older Neanderthal female. In April 2014, they announced that gene silencing might account for skeletal differences between modern humans and Neanderthals. Although the results were promising, scientists advised against drawing conclusions from such a small sample.
Despite impressive breakthroughs in DNA analysis, scientists still struggle to overcome DNA's fragility, especially in tropical regions where it degrades especially fast. Proteins, such as collagen in bones, is more abundant than DNA and persists better over time. By relying on protein sequencing, scientists might be able to peer further back in the history of life than is possible with DNA.
The relatively new field nicknamed evo-devo, that relates evolution to biological development, promises to change how we view the process of evolution. During embryonic development, researchers have found, the timing of genes being activated and deactivated can produce dramatic changes in body plans.
In January 2007, Nigel Goldenfeld and Carl Woese predicted that coming discoveries in how microbes swap genes — a process known as horizontal gene transfer, or HGT — would force a redefinition of organisms and "evolution itself." They wrote:
[M]icroorganisms have a remarkable ability to reconstruct their genomes in the face of dire environmental stresses, that in some cases, their collective interactions with viruses may be crucial to this. In such a situation, how valid is the very concept of an organism in isolation?
Will textbooks be rewritten soon? Stay tuned.
Narrative text and graphic design © 2007-2015 by Michon Scott - Updated August 7, 2015